Real Madrid host defending champions Chelsea in the second leg of the UEFA Champions League 2021-22 quarter-final at the Santiago Bernabeu in the early hours of Wednesday, April 13. 

The record European champions head into the second leg tie with a 3-1 advantage and are the odds-on favourites to advance. Chelsea, on the other hand, have been hit by a massive injury scare as striker Romelu Lukaku will be unavailable for selection through injury.

Furthermore, club captain Cesar Azpilicueta has tested negative for COVID-19 and will most likely return to the starting lineup.

For Madrid, defender Ferland Mendy was rested over the weekend and will most likely return to claim his spot.

Real Madrid vs Chelsea odds for UEFA Champions League 2021-22

Real Madrid: 2.48

Chelsea: 2.80

Draw: 3.45

Click here to check football betting odds.

Note: Odds are subject to change.

Real Madrid vs Chelsea recent form

Both Real Madrid and Chelsea enter the second leg tie with convincing wins in the league. The La Liga leaders got the better of Getafe 2-0 at home while Chelsea thumped Southampton 6-0 in an away fixture.

Real Madrid: W, W, W, L, W

Chelsea: W, L, L, W, W

Real Madrid vs Chelsea head-to-head

Real Madrid and Chelsea have played a total of six competitive matches in the past, with Chelsea winning three and two have been drawn. Interestingly enough, Madrid’s recent 3-1 triumph was their first-ever win over the Blues.

Real Madrid vs Chelsea head-to-head
Real Madrid Metrics Chelsea
1 Wins 3
3 Defeats 1
2 Draws 2

Real Madrid vs Chelsea prediction for UEFA Champions League 2021-22

Given the home advantage, Real Madrid are rightly expected to start as the outright favourites. Unlike Chelsea, who have lost two of their last three matches, Madrid have been exhilarating. Barring their 0-4 defeat to Barcelona, the team has won eight of their last nine games.

Featured photo: AFP / Adrian Dennis