An action-packed Premier League Gameweek 6 sees teams returning from the third-round play of the League Cup.

The Gameweek 6 schedule is headlined by a mouth-watering clash between Chelsea and Manchester City and the north London derby between Tottenham Hotspur and Arsenal. Manchester United, who crashed out of the League Cup, host Aston Villa while Liverpool travel to face newcomers Brentford.

Here are our picks for Premier League Gameweek 6:

Fantasy Premier League: Gameweek 6 tips to make your team

Best attacker: Michail Antonio

West Ham, fresh from knocking out Manchester United in the third round of the League Cup, will welcome back Michail Antonio who served a suspension after his red card against Southampton. The 31-year-old has four goals and three assists from his first four games and will look to exploit the frailties of the makeshift Leeds United defence this weekend.

Best defender: Trent Alexander-Arnold

Liverpool are expected to field Trent Alexander-Arnold in their line-up for the away trip to Brentford. The right-back sat out against Crystal Palace with a non-COVID-19 illness and his presence was slightly missed, given he is the main source for feeding in balls for Mohamed Salah and Sadio Mane in the Reds’ attack.

The 22-year-old has been a part of three clean sheets this season and has registered two assists as well, making him a must-have defender in the fantasy football team.

Budget player: Ismaila Sarr

Ismaila Sarr has registered three goals for Watford this season and is proving to be a good differential player despite the club’s indifferent form.

The Senegalese winger is coming off the back of a big 15-point haul against Norwich in Gameweek 5 and will look to trouble a Newcastle side that has conceded 13 goals so far in the campaign.

Fantasy Premier League stats for Gameweek 6 fixtures

Chelsea vs Manchester City

Chelsea have won four of their six fixtures against Manchester City across all competitions, and are currently on a three-match winning streak against the Cityzens.

Manchester City have kept a clean sheet in their last four Premier League matches.

Chelsea have won their last three league home matches, scoring two goals on average.

There has been a winner in all of the last six matches played between the teams.

The last draw between the two teams dates back to January 2015 when David Silva’s strike cancelled out Loic Remy’s first-half goal.

Tottenham Hotspur vs Arsenal

Less than three goals have been scored (both teams combined) in five of Arsenal's last six Premier League games.

Three or more goals have been scored (both teams combined) in five of Tottenham's last six away premier league games.

Tottenham have conceded two or more goals in five of their last six away premier league games.

Tottenham scored first on their last two trips to the Emirates Stadium but failed to win both (Draw 1, Loss 1).

Featured photo: AFP / Shaun Botterill